| Molecular Formula | C62H84N14O6 |
| Molar Mass | 1121.45 |
| Density | 1.33±0.1 g/cm3(Predicted) |
| Solubility | 10 mM in DMSO |
| Appearance | solid |
| Color | White to pale-yellow |
| pKa | 12.62±0.40(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 0.892 ml | 4.459 ml | 8.917 ml |
| 5 mM | 0.178 ml | 0.892 ml | 1.783 ml |
| 10 mM | 0.089 ml | 0.446 ml | 0.892 ml |
| 5 mM | 0.018 ml | 0.089 ml | 0.178 ml |
| biological activity | SM-164 is a potent, non-peptide, cell-permeable XIAP antagonist, targeting the BIR2 and BIR3 domains has an IC50 value of 1.39 nM. SM-164 can induce apoptosis and tumor regression. |
| Target | TargetValue XIAP (Cell-free assay) 1.39 nM |
| Target | Value |
| XIAP (Cell-free assay) | 1.39 nM |